| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-2 |
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| Ligand | BDBM637528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Measurement of Mat2A inhibition is performed in 384 well format absorbance-based assay |
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| IC50 | 32.0±n/a nM |
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| Citation |  BELL, AS; BESNARD, J; BRADLEY, AR; GREEN, L; HAAP, W; KOCER, B; KUGLSTATTER, A; LUCAS, X; MATTEI, P; MAZUNIN, D; RIEMER, C; VAN HOORN, WP PYRAZOLEAMIDE DERIVATIVES US Patent US20230382911 Publication Date 11/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase isoform type-2 |
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| Name: | S-adenosylmethionine synthase isoform type-2 |
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| Synonyms: | AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II |
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| Type: | Protein |
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| Mol. Mass.: | 43659.65 |
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| Organism: | Human |
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| Description: | P31153 |
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| Residue: | 395 |
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| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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| BDBM637528 |
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| n/a |
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| Name | BDBM637528 |
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| Synonyms: | (3-amino-6-(2,2- difluorocyclopropyl)-1H- pyrazolo[3,4-b]pyridin-1-yl)(2- methoxyphenyl)methanone | US20230382911, Example 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F2N4O2 |
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| Mol. Mass. | 344.3155 |
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| SMILES | COc1ccccc1C(=O)n1nc(N)c2ccc(nc12)C1CC1(F)F |
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| Structure | 
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