| Reaction Details |
|---|
 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-2 |
|---|
| Ligand | BDBM637556 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Measurement of Mat2A inhibition is performed in 384 well format absorbance-based assay |
|---|
| IC50 | 19.0±n/a nM |
|---|
| Citation |  BELL, AS; BESNARD, J; BRADLEY, AR; GREEN, L; HAAP, W; KOCER, B; KUGLSTATTER, A; LUCAS, X; MATTEI, P; MAZUNIN, D; RIEMER, C; VAN HOORN, WP PYRAZOLEAMIDE DERIVATIVES US Patent US20230382911 Publication Date 11/30/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| S-adenosylmethionine synthase isoform type-2 |
|---|
| Name: | S-adenosylmethionine synthase isoform type-2 |
|---|
| Synonyms: | AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43659.65 |
|---|
| Organism: | Human |
|---|
| Description: | P31153 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
|
|
|
|---|
| BDBM637556 |
|---|
| n/a |
|---|
| Name | BDBM637556 |
|---|
| Synonyms: | (3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-1-yl)(2- methylpyridin-methylpyridine-3- yl)methanone | US20230382911, Example 68 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15N5O |
|---|
| Mol. Mass. | 293.3232 |
|---|
| SMILES | Cc1ncccc1C(=O)n1nc(N)c2ccc(nc12)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
