| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 7 |
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| Ligand | BDBM556300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | hPGDH Inhibitor Screening Biochemical Assay |
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| IC50 | 1.80±n/a nM |
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| Citation |  RAI, R; BOOTH, R INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF US Patent US20230390274 Publication Date 12/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 7 |
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| Name: | 5-hydroxytryptamine receptor 7 |
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| Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 53573.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34969 |
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| Residue: | 479 |
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| Sequence: | MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
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| BDBM556300 |
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| n/a |
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| Name | BDBM556300 |
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| Synonyms: | US11345702, Table 1.18 | US20230390274, Compound A-26 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClN3O3 |
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| Mol. Mass. | 411.881 |
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| SMILES | CCOC(=O)c1nc2cc(ccc2n1-c1cccc(Cl)c1)C(=O)N1CCCCC1 |$;;O;;;;;;;;;;;;;;;;;;;;;;;;;;$| |
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| Structure | 
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