| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclic GMP-AMP synthase |
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| Ligand | BDBM639734 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibition Assay |
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| IC50 | 6.77±n/a nM |
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| Citation |  AHMED, A; MARTINEZ BROKAW, C; CARSON, CA; CONNER, SE; FORTNER, KC; FRANCISKOVICH, JB; GERNERT, DL; GREEN, SJ; LUGAR, III, CW; MARIMUTHU, J; NAGARAJAN, S; NICOLAOU, C; ONOBUN, E; STOUT, SL; TROMICZAK, EG; VARIN, T cGAS INHIBITORS US Patent US20230391786 Publication Date 12/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclic GMP-AMP synthase |
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| Name: | Cyclic GMP-AMP synthase |
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| Synonyms: | 2.7.7.86 | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | h-cGAS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58845.55 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117333 |
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| Residue: | 522 |
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| Sequence: | MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
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| BDBM639734 |
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| n/a |
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| Name | BDBM639734 |
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| Synonyms: | 2-((6,7-Dichloro-2-(5-methyl-1,3,4-thiadiazol-2-yl)-10-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydropyrazino[1,2-a]indol-9-yl)oxy)acetonitrile | US20230391786, Example 203 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15Cl2N7OS |
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| Mol. Mass. | 460.34 |
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| SMILES | Cc1nnc(s1)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 |
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| Structure | 
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