Reaction Details |
| Report a problem with these data |
Target | Cyclic GMP-AMP synthase |
---|
Ligand | BDBM639763 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Inhibition Assay |
---|
IC50 | 3.76±n/a nM |
---|
Citation | AHMED, A; MARTINEZ BROKAW, C; CARSON, CA; CONNER, SE; FORTNER, KC; FRANCISKOVICH, JB; GERNERT, DL; GREEN, SJ; LUGAR, III, CW; MARIMUTHU, J; NAGARAJAN, S; NICOLAOU, C; ONOBUN, E; STOUT, SL; TROMICZAK, EG; VARIN, T cGAS INHIBITORS US Patent US20230391786 Publication Date 12/7/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cyclic GMP-AMP synthase |
---|
Name: | Cyclic GMP-AMP synthase |
Synonyms: | 2.7.7.86 | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | h-cGAS |
Type: | PROTEIN |
Mol. Mass.: | 58845.55 |
Organism: | Homo sapiens |
Description: | ChEMBL_117333 |
Residue: | 522 |
Sequence: | MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
|
|
|
BDBM639763 |
---|
n/a |
---|
Name | BDBM639763 |
Synonyms: | (S)N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetamide | US20230391786, Example 232 |
Type | Small organic molecule |
Emp. Form. | C18H15Cl2N5O2 |
Mol. Mass. | 404.25 |
SMILES | CC(=O)N[C@H]1CCn2c1c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 |r| |
Structure |
|