| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [T315I] |
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| Ligand | BDBM640374 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Kinase Assay |
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| IC50 | <5±n/a nM |
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| Citation |  Wang, Y; Xing, Q Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity US Patent US11840535 Publication Date 12/12/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ABL1 [T315I] |
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| Name: | Tyrosine-protein kinase ABL1 [T315I] |
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| Synonyms: | ABL | ABL Mutant (T315I) | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL (T315I) | Tyrosine-protein kinase ABL1 (T315I) | c-ABL | c-abl (T315I) | p150 |
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| Type: | n/a |
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| Mol. Mass.: | 122909.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00519 (T315I) |
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| Residue: | 1130 |
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| Sequence: | MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIIIEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP
SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP
KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS
CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV
TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL
PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE
RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK
FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
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| BDBM640374 |
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| n/a |
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| Name | BDBM640374 |
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| Synonyms: | Preparation of 3-((4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)-4-methyl-N-(4-((4-methyl piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | US11840535, Example 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H30F3N7O |
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| Mol. Mass. | 561.6007 |
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| SMILES | CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cn(C)c4ncnc(N)c34)cc2C(F)(F)F)CC1 |
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| Structure | 
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