| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM642270 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Arginase |
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| IC50 | 9.10±n/a nM |
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| Citation |  Kurhade, S; Dömling, A Arginase inhibitors US Patent US11845767 Publication Date 12/19/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM642270 |
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| n/a |
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| Name | BDBM642270 |
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| Synonyms: | (5-amino-5-(1-(2-((2,4- difluorobenzyl)amino)-2-oxoethyl)-1H- tetrazol-5-yl)pentyl)boronic acid | US11845767, Example 315 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H21BF2N6O3 |
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| Mol. Mass. | 382.173 |
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| SMILES | NC(CCCCB(O)O)c1nnnn1CC(=O)NCc1ccc(F)cc1F |
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| Structure | 
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