| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-2, mitochondrial |
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| Ligand | BDBM642309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Arginase |
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| IC50 | 30.0±n/a nM |
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| Citation |  Kurhade, S; Dömling, A Arginase inhibitors US Patent US11845767 Publication Date 12/19/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Arginase-2, mitochondrial |
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| Name: | Arginase-2, mitochondrial |
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| Synonyms: | ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38576.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978892 |
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| Residue: | 354 |
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| Sequence: | MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
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| BDBM642309 |
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| n/a |
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| Name | BDBM642309 |
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| Synonyms: | (+)-(R)-(5-amino-5-(1-(2-oxo-2-(prop-2- yn-1-ylamino)ethyl)-1H-tetrazol-5- yl)pentyl)boronic acid | US11845767, Example 355 |
|---|
| Type | Small organic molecule |
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| Emp. Form. | C11H19BN6O3 |
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| Mol. Mass. | 294.118 |
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| SMILES | N[C@H](CCCCB(O)O)c1nnnn1CC(=O)NCC#C |
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| Structure | 
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