| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
|---|
| Ligand | BDBM642537 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PSMA inhibitory Activity Assay |
|---|
| Ki | 0.080±n/a nM |
|---|
| Citation |  YANG, X; YANG, Z; XI, Z; LIU, F; DUAN, X PSMA INHIBITOR, COMPOUND AND APPLICATION US Patent US20230414794 Publication Date 12/28/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate carboxypeptidase 2 |
|---|
| Name: | Glutamate carboxypeptidase 2 |
|---|
| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84333.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1497035 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
|
|
|
|---|
| BDBM642537 |
|---|
| n/a |
|---|
| Name | BDBM642537 |
|---|
| Synonyms: | US20230414794, Compound S2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23IN4O9 |
|---|
| Mol. Mass. | 578.3118 |
|---|
| SMILES | OC(=O)[C@H](CCCCNC(=O)c1ccc(I)cc1)NC(=O)N[C@@H](CNC(=O)C(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
