| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK [14-552] |
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| Ligand | BDBM324286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro BTK Kinase Assay |
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| IC50 | <1.000±n/a nM |
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| Citation |  Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent US11858926 Publication Date 1/2/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK [14-552] |
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| Name: | Tyrosine-protein kinase BTK [14-552] |
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| Synonyms: | Tyrosine-protein kinase BTK (14-552) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62318.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06187[14-552] |
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| Residue: | 539 |
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| Sequence: | SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNP
PPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIR
YNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPE
EDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWR
ARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAG
KYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRL
KYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK
EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF
QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
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| BDBM324286 |
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| n/a |
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| Name | BDBM324286 |
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| Synonyms: | 1-(tert-butyl)-N—((R)-2-((R)-2-hydroxypropyl)-8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide | US10189829, Compound 29 | US10227341, Compound 29 | US10961237, Compound 29 | US11858926, Compound 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N10O2 |
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| Mol. Mass. | 544.6512 |
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| SMILES | C[C@@H](O)CN1CC[C@@H](NC(=O)c2cn(nn2)C(C)(C)C)c2ccc(cc2C1)-c1ccnc(Nc2cnn(C)c2)n1 |r| |
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| Structure | 
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