Reaction Details |
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Target | Tyrosine-protein kinase BTK [14-552] |
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Ligand | BDBM324312 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro BTK Kinase Assay |
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IC50 | <1.000±n/a nM |
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Citation | Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent US11858926 Publication Date 1/2/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK [14-552] |
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Name: | Tyrosine-protein kinase BTK [14-552] |
Synonyms: | Tyrosine-protein kinase BTK (14-552) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 62318.43 |
Organism: | Homo sapiens (Human) |
Description: | Q06187[14-552] |
Residue: | 539 |
Sequence: | SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNP
PPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIR
YNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPE
EDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWR
ARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAG
KYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRL
KYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK
EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF
QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
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BDBM324312 |
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n/a |
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Name | BDBM324312 |
Synonyms: | 1-(tert-butyl)-N-(2-((R)- 2-hydroxypropyl)-8-(2- ((1-methyl-1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-2,3,4,5-tetrahydro- 1H-benzo[c]azepin-5-yl)- 1H-1,2,3-triazole-4- carboxamide | US10189829, Compound 77 | US10227341, Compound 77 | US10961237, Compound 77 | US11858926, Compound 77 |
Type | Small organic molecule |
Emp. Form. | C28H36N10O2 |
Mol. Mass. | 544.6512 |
SMILES | C[C@@H](O)CN1CCC(NC(=O)c2cn(nn2)C(C)(C)C)c2ccc(cc2C1)-c1ccnc(Nc2cnn(C)c2)n1 |r| |
Structure |
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