| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK [14-552] |
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| Ligand | BDBM324346 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro BTK Kinase Assay |
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| IC50 | <1.000±n/a nM |
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| Citation |  Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent US11858926 Publication Date 1/2/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase BTK [14-552] |
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| Name: | Tyrosine-protein kinase BTK [14-552] |
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| Synonyms: | Tyrosine-protein kinase BTK (14-552) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62318.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06187[14-552] |
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| Residue: | 539 |
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| Sequence: | SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNP
PPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIR
YNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPE
EDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWR
ARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAG
KYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRL
KYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK
EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF
QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
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| BDBM324346 |
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| n/a |
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| Name | BDBM324346 |
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| Synonyms: | N-(2-(2-hydroxyethyl)-8- (2-((1-methyl-1H- pyrazol-4- yl)amino)pyrimidin-4- yl)-2,3,4,5-tetrahydro- 1H-benzo[c]azepin- 5-yl)-5- (1-methylcyclopropyl)- 1,3,4-oxadiazole-2- carboxamide | US10189829, Compound 125 | US10227341, Compound 125 | US10961237, Compound 125 | US11858926, Compound 125 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N9O3 |
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| Mol. Mass. | 529.5935 |
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| SMILES | Cn1cc(Nc2nccc(n2)-c2ccc3C(CCN(CCO)Cc3c2)NC(=O)c2nnc(o2)C2(C)CC2)cn1 |
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| Structure | 
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