Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
Ligand | BDBM642877 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | HSD2 Activity | ||
IC50 | 100±n/a nM | ||
Citation | Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Glycyrrhetinic acid derivatives for use in treating hyperkalemia US Patent US11858959 Publication Date 1/2/2024 | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase type 2 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 | ||
Type: | Enzyme | ||
Mol. Mass.: | 44141.72 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Purified recombinant human 11beta-HSD2. | ||
Residue: | 405 | ||
Sequence: |
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BDBM642877 | |||
n/a | |||
Name | BDBM642877 | ||
Synonyms: | (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-{[2-(methylsulfanyl)acetyl]oxy}-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid | US11858959, Compound 701-1 | ||
Type | Small organic molecule | ||
Emp. Form. | C40H56O10S | ||
Mol. Mass. | 728.932 | ||
SMILES | CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)C |t:20| | ||
Structure |