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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
| Ligand | BDBM642909 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HSD2 Activity | ||
| IC50 | 126±n/a nM | ||
| Citation |  Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Glycyrrhetinic acid derivatives for use in treating hyperkalemia US Patent US11858959 Publication Date 1/2/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase type 2 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 44141.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Purified recombinant human 11beta-HSD2. | ||
| Residue: | 405 | ||
| Sequence: |
| ||
| BDBM642909 | |||
| n/a | |||
| Name | BDBM642909 | ||
| Synonyms: | (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(((2-morpholinoethyl)carbamoyl)oxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid | US11858959, Compound 286-4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C42H60N2O11 | ||
| Mol. Mass. | 768.9326 | ||
| SMILES | Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)NCCN1CCOCC1 |t:29| | ||
| Structure | 
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