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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643296 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.600±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643296 | |||
| n/a | |||
| Name | BDBM643296 | ||
| Synonyms: | US20240002391, Compound 8 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H20N6O2 | ||
| Mol. Mass. | 364.4011 | ||
| SMILES | COc1nc(N[C@H]2C[C@](C)(O)C2)nn2ccc(-c3ccn4nccc4c3)c12 |r,wU:8.9,wD:6.5,8.8,(-2.29,.7,;-.95,-.07,;-.95,-1.61,;.38,-2.38,;.38,-3.92,;1.7,-4.69,;3.03,-3.92,;4.52,-4.32,;4.92,-2.83,;4.92,-1.29,;6.25,-2.06,;3.43,-2.43,;-.95,-4.69,;-2.29,-3.92,;-3.72,-4.41,;-4.62,-3.19,;-3.75,-1.86,;-4.24,-.4,;-5.74,-.07,;-6.25,1.42,;-5.22,2.59,;-5.34,4.13,;-3.91,4.72,;-2.91,3.54,;-3.72,2.22,;-3.21,.8,;-2.29,-2.38,)| | ||
| Structure | 
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