Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643323 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.700±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
| ||
| BDBM643323 | |||
| n/a | |||
| Name | BDBM643323 | ||
| Synonyms: | US20240002391, Compound 53 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25N7O2 | ||
| Mol. Mass. | 419.4796 | ||
| SMILES | COc1nc(N[C@@H]2CC[C@@H](CC2)NC(C)=O)nn2ccc(-c3ccc4nccn4c3)c12 |r,wD:6.5,9.12,(-1.55,.73,;-2.88,-.04,;-2.88,-1.58,;-1.55,-2.35,;-1.55,-3.89,;-.22,-4.66,;1.12,-3.89,;1.12,-2.35,;2.45,-1.58,;3.79,-2.35,;3.79,-3.89,;2.45,-4.66,;5.12,-1.58,;6.45,-2.35,;7.79,-1.58,;6.45,-3.89,;-2.88,-4.66,;-4.22,-3.89,;-5.68,-4.37,;-6.59,-3.12,;-5.68,-1.87,;-6,-.37,;-7.47,.11,;-7.79,1.61,;-6.64,2.64,;-6.64,4.18,;-5.18,4.66,;-4.27,3.41,;-5.18,2.17,;-4.86,.66,;-4.22,-2.35,)| | ||
| Structure | 
| ||