Reaction Details | |||
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Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
Ligand | BDBM643323 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | DYRK1A kinase assay | ||
EC50 | 0.700±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
Type: | Enzyme | ||
Mol. Mass.: | 85616.61 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13627 | ||
Residue: | 763 | ||
Sequence: |
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BDBM643323 | |||
n/a | |||
Name | BDBM643323 | ||
Synonyms: | US20240002391, Compound 53 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H25N7O2 | ||
Mol. Mass. | 419.4796 | ||
SMILES | COc1nc(N[C@@H]2CC[C@@H](CC2)NC(C)=O)nn2ccc(-c3ccc4nccn4c3)c12 |r,wD:6.5,9.12,(-1.55,.73,;-2.88,-.04,;-2.88,-1.58,;-1.55,-2.35,;-1.55,-3.89,;-.22,-4.66,;1.12,-3.89,;1.12,-2.35,;2.45,-1.58,;3.79,-2.35,;3.79,-3.89,;2.45,-4.66,;5.12,-1.58,;6.45,-2.35,;7.79,-1.58,;6.45,-3.89,;-2.88,-4.66,;-4.22,-3.89,;-5.68,-4.37,;-6.59,-3.12,;-5.68,-1.87,;-6,-.37,;-7.47,.11,;-7.79,1.61,;-6.64,2.64,;-6.64,4.18,;-5.18,4.66,;-4.27,3.41,;-5.18,2.17,;-4.86,.66,;-4.22,-2.35,)| | ||
Structure | ![]() |