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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643396 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.500±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643396 | |||
| n/a | |||
| Name | BDBM643396 | ||
| Synonyms: | US20240002391, Compound 208 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N8O3 | ||
| Mol. Mass. | 450.4936 | ||
| SMILES | COCC(=O)N[C@@]1(C)C[C@@H](C1)Nc1nc(OC)c2c(ccn2n1)-c1ccc2nnn(C)c2c1 |r,wU:6.5,wD:9.11,6.6,(8.91,-2.04,;7.57,-2.81,;6.24,-2.04,;4.91,-2.81,;4.91,-4.35,;3.57,-2.04,;2.24,-2.81,;2.24,-1.27,;1.84,-4.3,;.35,-3.9,;.75,-2.41,;-.98,-4.67,;-2.32,-3.9,;-2.32,-2.36,;-3.65,-1.59,;-3.65,-.05,;-4.98,.72,;-4.98,-2.36,;-6.45,-1.88,;-7.35,-3.13,;-6.45,-4.37,;-4.98,-3.9,;-3.65,-4.67,;-6.92,-.42,;-8.43,-.1,;-8.91,1.37,;-7.88,2.51,;-8.04,4.04,;-6.63,4.67,;-5.6,3.52,;-4.07,3.69,;-6.37,2.19,;-5.89,.73,)| | ||
| Structure | 
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