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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643415 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.500±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643415 | |||
| n/a | |||
| Name | BDBM643415 | ||
| Synonyms: | US20240002391, Compound 236 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H19N7O2 | ||
| Mol. Mass. | 365.3892 | ||
| SMILES | CO[C@@H]1C[C@@H](C1)Nc1nc(OC)c2c(ccn2n1)-c1cnc2nccn2c1 |r,wD:4.6,2.1,(6.31,-.46,;6.31,-2,;4.98,-2.77,;4.51,-4.3,;3.02,-3.9,;3.42,-2.41,;1.69,-4.67,;.35,-3.9,;.35,-2.36,;-.98,-1.59,;-.98,-.05,;-2.32,.72,;-2.32,-2.36,;-3.78,-1.88,;-4.69,-3.13,;-3.78,-4.37,;-2.32,-3.9,;-.98,-4.67,;-4.26,-.42,;-5.76,-.1,;-6.24,1.37,;-5.21,2.51,;-5.37,4.04,;-3.96,4.67,;-2.93,3.52,;-3.7,2.19,;-3.23,.73,)| | ||
| Structure | 
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