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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643419 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.700±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643419 | |||
| n/a | |||
| Name | BDBM643419 | ||
| Synonyms: | US20240002391, Compound 245 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N7O2 | ||
| Mol. Mass. | 393.4423 | ||
| SMILES | CO[C@@H]1CC[C@@H](CC1)Nc1nc(OC)c2c(ccn2n1)-c1cnc2nccn2c1 |r,wD:5.8,2.1,(5.96,-.05,;5.96,-1.59,;4.63,-2.36,;4.63,-3.9,;3.3,-4.67,;1.96,-3.9,;1.96,-2.36,;3.3,-1.59,;.63,-4.67,;-.71,-3.9,;-.71,-2.36,;-2.04,-1.59,;-2.04,-.05,;-3.37,.72,;-3.37,-2.36,;-4.84,-1.88,;-5.74,-3.13,;-4.84,-4.37,;-3.37,-3.9,;-2.04,-4.67,;-5.31,-.42,;-6.82,-.1,;-7.3,1.37,;-6.27,2.51,;-6.43,4.04,;-5.02,4.67,;-3.99,3.52,;-4.76,2.19,;-4.28,.73,)| | ||
| Structure | 
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