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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643420 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.600±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643420 | |||
| n/a | |||
| Name | BDBM643420 | ||
| Synonyms: | US20240002391, Compound 250 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21F2N7O2 | ||
| Mol. Mass. | 429.4232 | ||
| SMILES | COc1nc(N[C@H]2CC[C@H](CC2)OC(F)F)nn2ccc(-c3cnc4nccn4c3)c12 |r,wD:6.5,9.12,(-4.04,.72,;-2.71,-.05,;-2.71,-1.59,;-1.37,-2.36,;-1.37,-3.9,;-.04,-4.67,;1.29,-3.9,;2.63,-4.67,;3.96,-3.9,;3.96,-2.36,;2.63,-1.59,;1.29,-2.36,;5.3,-1.59,;6.63,-2.36,;7.96,-1.59,;6.63,-3.9,;-2.71,-4.67,;-4.04,-3.9,;-5.5,-4.37,;-6.41,-3.13,;-5.5,-1.88,;-5.98,-.42,;-7.49,-.1,;-7.96,1.37,;-6.93,2.51,;-7.09,4.04,;-5.69,4.67,;-4.66,3.52,;-5.43,2.19,;-4.95,.73,;-4.04,-2.36,)| | ||
| Structure | 
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