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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643423 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.400±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643423 | |||
| n/a | |||
| Name | BDBM643423 | ||
| Synonyms: | US20240002391, Compound 257 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N7O2 | ||
| Mol. Mass. | 393.4423 | ||
| SMILES | COc1nc(N[C@H]2CC[C@](C)(O)CC2)nn2ccc(-c3cnc4nccn4c3)c12 |r,wU:9.10,wD:6.5,9.9,(-2.71,.72,;-1.37,-.05,;-1.37,-1.59,;-.04,-2.36,;-.04,-3.9,;1.29,-4.67,;2.63,-3.9,;3.96,-4.67,;5.3,-3.9,;5.3,-2.36,;5.3,-.82,;6.63,-1.59,;3.96,-1.59,;2.63,-2.36,;-1.37,-4.67,;-2.71,-3.9,;-4.17,-4.37,;-5.08,-3.13,;-4.17,-1.88,;-4.65,-.42,;-6.15,-.1,;-6.63,1.37,;-5.6,2.51,;-5.76,4.04,;-4.35,4.67,;-3.32,3.52,;-4.09,2.19,;-3.62,.73,;-2.71,-2.36,)| | ||
| Structure | 
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