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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643588 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.500±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643588 | |||
| n/a | |||
| Name | BDBM643588 | ||
| Synonyms: | US20240002391, Compound 711 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23F2N7O2 | ||
| Mol. Mass. | 431.4391 | ||
| SMILES | COc1nc(N[C@H]2C[C@](C)(O)C2)nn2ccc(-c3ccc(N=N)c(NCC(F)F)c3)c12 |r,wU:8.9,wD:6.5,8.8,(.31,.02,;-1.02,-.77,;-1.01,-2.31,;.35,-3.19,;.35,-4.73,;1.69,-5.5,;3.02,-4.73,;4.51,-5.13,;4.9,-3.64,;4.9,-2.1,;6.24,-2.87,;3.42,-3.25,;-.98,-5.5,;-2.32,-4.73,;-3.78,-5.21,;-4.69,-3.96,;-3.78,-2.72,;-4.26,-1.25,;-5.76,-.93,;-6.24,.53,;-5.21,1.68,;-5.68,3.14,;-4.65,4.29,;-3.7,1.36,;-2.93,2.69,;-1.4,2.85,;-.77,4.26,;-1.68,5.5,;.76,4.42,;-3.23,-.11,;-2.32,-3.19,)| | ||
| Structure | 
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