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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643637 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.400±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643637 | |||
| n/a | |||
| Name | BDBM643637 | ||
| Synonyms: | US20240002391, Compound 905 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H23F3N8O2 | ||
| Mol. Mass. | 488.4656 | ||
| SMILES | COc1nc(N[C@H]2C[C@](C)(C2)NC(C)=O)nn2ccc(-c3ccc4nnn(CC(F)(F)F)c4c3)c12 |r,wU:8.8,wD:6.5,8.11,(-3.61,-.19,;-2.28,-.96,;-2.28,-2.5,;-.95,-3.27,;-.95,-4.81,;.4,-5.56,;1.72,-4.78,;3.21,-5.16,;3.59,-3.66,;3.59,-2.12,;2.1,-3.28,;4.92,-2.88,;6.26,-3.63,;7.58,-2.84,;6.26,-5.17,;-2.28,-5.58,;-3.61,-4.81,;-5.08,-5.28,;-5.98,-4.04,;-5.08,-2.79,;-5.57,-1.33,;-7.09,-1.03,;-7.58,.42,;-6.57,1.58,;-6.75,3.11,;-5.35,3.76,;-4.31,2.63,;-2.78,2.81,;-2.17,4.23,;-1.56,5.64,;-.76,3.62,;-3.59,4.83,;-5.06,1.28,;-4.56,-.17,;-3.61,-3.27,)| | ||
| Structure | 
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