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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643658 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.400±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643658 | |||
| n/a | |||
| Name | BDBM643658 | ||
| Synonyms: | US20240002391, Compound 948 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22N8O | ||
| Mol. Mass. | 402.4524 | ||
| SMILES | COc1nc(NC2CCC(C)(CC2)C#N)nn2ccc(-c3cnc4nccn4c3)c12 |(-1.95,-5.27,;-.62,-4.5,;-.62,-2.96,;.71,-2.19,;.71,-.65,;2.05,.12,;2.05,1.66,;.71,2.43,;.71,3.97,;2.05,4.74,;2.77,6.1,;3.38,3.97,;3.38,2.43,;1.32,6.1,;.6,7.46,;-.62,.12,;-1.95,-.65,;-3.42,-.17,;-4.32,-1.42,;-3.42,-2.67,;-3.9,-4.13,;-2.87,-5.28,;-3.34,-6.74,;-4.85,-7.06,;-5.62,-8.39,;-7.12,-8.07,;-7.28,-6.54,;-5.88,-5.92,;-5.4,-4.45,;-1.95,-2.19,)| | ||
| Structure | 
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