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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643667 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.500±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643667 | |||
| n/a | |||
| Name | BDBM643667 | ||
| Synonyms: | US20240002391, Compound 1038 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24N6O2 | ||
| Mol. Mass. | 416.4757 | ||
| SMILES | CNC(=O)[C@@]1(C)C[C@@H](C1)Nc1nc(OC)c2c(ccn2n1)-c1ccc2ncccc2c1 |r,wU:4.3,wD:7.9,4.4,(7.57,-2.27,;6.24,-3.04,;4.91,-2.27,;4.9,-.73,;3.57,-3.04,;3.57,-1.5,;3.17,-4.52,;1.69,-4.12,;2.08,-2.64,;.35,-4.89,;-.98,-4.12,;-.98,-2.58,;-2.32,-1.81,;-2.32,-.27,;-3.65,.5,;-3.65,-2.58,;-5.11,-2.11,;-6.02,-3.35,;-5.11,-4.6,;-3.65,-4.12,;-2.32,-4.89,;-5.59,-.64,;-7.1,-.32,;-7.57,1.14,;-6.54,2.29,;-7.02,3.75,;-5.99,4.89,;-4.48,4.57,;-4.01,3.11,;-5.04,1.97,;-4.56,.5,)| | ||
| Structure | 
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