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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM643695 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DYRK1A kinase assay | ||
| EC50 | 0.700±n/a nM | ||
| Citation |  Mittapalli, GK; Mak, CC; Turner, LD; Hofilena, BJ; Vakiti, RR; Eastman, BW; Wallace, DM 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF US Patent US20240002391 Publication Date 1/4/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM643695 | |||
| n/a | |||
| Name | BDBM643695 | ||
| Synonyms: | US20240002391, Compound 1099 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23F2N7O | ||
| Mol. Mass. | 451.4718 | ||
| SMILES | COc1nc(N[C@H]2C[C@]3(CCN3CC(F)F)C2)nn2ccc(-c3ccc4nccnc4c3)c12 |r,wD:6.5,8.11,(-2.78,1.77,;-1.44,1,;-1.44,-.54,;-.11,-1.31,;-.11,-2.85,;1.22,-3.62,;2.56,-2.85,;4.04,-3.25,;4.44,-1.77,;4.84,-.28,;6.33,-.68,;5.93,-2.16,;6.7,-3.5,;5.93,-4.83,;4.39,-4.83,;6.7,-6.16,;2.96,-1.37,;-1.44,-3.62,;-2.78,-2.85,;-4.24,-3.33,;-5.15,-2.08,;-4.24,-.84,;-4.72,.63,;-6.22,.95,;-6.7,2.41,;-5.67,3.56,;-6.15,5.02,;-5.12,6.16,;-3.61,5.84,;-3.13,4.38,;-4.16,3.24,;-3.69,1.77,;-2.78,-1.31,)| | ||
| Structure | 
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