| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase SIK1 |
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| Ligand | BDBM647330 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro SIK2 Kinase Assay |
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| IC50 | 775±n/a nM |
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| Citation |  Wein, MN; Greenlee, WJ SALT INDUCIBLE KINASE INHIBITORS US Patent US20240025892 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase SIK1 |
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| Name: | Serine/threonine-protein kinase SIK1 |
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| Synonyms: | SIK | SIK1 | SIK1_HUMAN | SNF1LK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84908.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774213 |
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| Residue: | 783 |
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| Sequence: | MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK
TRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH
LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPL
STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGR
FRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSN
LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPAR
QPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFP
VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTR
LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLAS
PFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFL
GLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRL
LQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASP
VASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFV
LVQ
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| BDBM647330 |
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| n/a |
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| Name | BDBM647330 |
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| Synonyms: | US20240025892, Example 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15N5O |
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| Mol. Mass. | 353.3767 |
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| SMILES | O=C(NCc1cccnc1)c1ccc2c(cnn2c1)-c1ccc(cc1)C#N |
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| Structure | 
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