| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity nerve growth factor receptor [G667C] |
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| Ligand | BDBM647654 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Activity of the Compounds of the Invention Against ROS1, NTRK and ALK and their Drug-Resistant Kinases |
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| IC50 | 2.75±n/a nM |
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| Citation |  LI, J; LIANG, A; NIU, C; WU, Y COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF US Patent US20240025908 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity nerve growth factor receptor [G667C] |
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| Name: | High affinity nerve growth factor receptor [G667C] |
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| Synonyms: | High affinity nerve growth factor receptor (TrkA)(G667C) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 87544.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04629 (G667C) |
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| Residue: | 796 |
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| Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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| BDBM647654 |
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| n/a |
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| Name | BDBM647654 |
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| Synonyms: | US20240025908, Example 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20FN7O2 |
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| Mol. Mass. | 385.3955 |
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| SMILES | CCOc1ncc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NOCCN3)c2n1 |r,t:21| |
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| Structure | 
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