| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM312070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Assay for IDO1 Enzymatic Activity Determination |
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| IC50 | 2200±n/a nM |
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| Citation |  Crosignani, S; Cauwenberghs, S; Driessens, G; Deroose, F Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors US Patent US9603836 Publication Date 3/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM312070 |
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| n/a |
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| Name | BDBM312070 |
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| Synonyms: | (-)-(R)-3-(5-chloro-1H- indol-3-yl)pyrrolidine- 2,5-dione | US9603836, Compound 6 | US9949951, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9ClN2O2 |
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| Mol. Mass. | 248.665 |
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| SMILES | Clc1ccc2[nH]cc([C@H]3CC(=O)NC3=O)c2c1 |r| |
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| Structure | 
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