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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | ||
| Ligand | BDBM648851 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | CDK1/Cyclin B1 ADP-Glo Kinase Assay | ||
| IC50 | 1.000±n/a nM | ||
| Citation |  VERNIER, W; NGUYEN, QN; REZAYEE, N; GOMEZ, L; ZHANG, C; MILLER, III, TF; MANBY, FR AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE US Patent US20240034731 Publication Date 2/1/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | |||
| Name: | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | ||
| Synonyms: | CDK1/B | CDK1/Cyclin B | CDK1/CyclinB | Cyclin B/Dependent Kinase 1 (CDK1) | Cyclin-Dependent Kinase 1 (CDK1) | Cyclin-dependent kinase 1/cyclin B1 | Cyclin-dependent kinase/G2/mitotic-specific cyclin 1 | cdk1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | CDK1/Cyclin B complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 1 | ||
| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 34101.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P06493 | ||
| Residue: | 297 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G2/mitotic-specific cyclin-B1 | ||
| Synonyms: | CCNB | CCNB1 | CCNB1_HUMAN | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48340.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14635 | ||
| Residue: | 433 | ||
| Sequence: |
| ||
| BDBM648851 | |||
| n/a | |||
| Name | BDBM648851 | ||
| Synonyms: | 8-(1,1-difluoro-5-azaspiro[2.4]heptan-5-yl)-N- ((1s,4s)-4-((dimethylamino)methyl)cyclohexyl)-6- methylpyrido[3,4-d]pyrimidin-2-amine | US20240034731, Compound 45 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H32F2N6 | ||
| Mol. Mass. | 430.5372 | ||
| SMILES | CN(C)C[C@H]1CC[C@H](CC1)Nc1ncc2cc(C)nc(N3CCC4(CC4(F)F)C3)c2n1 |r,wU:7.10,4.3,(-8.46,-4.26,;-7.13,-3.49,;-7.13,-1.95,;-5.79,-4.26,;-4.46,-3.49,;-4.46,-1.95,;-3.13,-1.18,;-1.79,-1.95,;-1.79,-3.49,;-3.13,-4.26,;-.46,-1.18,;.88,-1.95,;.88,-3.49,;2.21,-4.26,;3.54,-3.49,;4.88,-4.26,;6.21,-3.49,;7.54,-4.26,;6.21,-1.95,;4.88,-1.18,;4.88,.36,;3.63,1.26,;4.11,2.73,;5.65,2.73,;5.81,4.26,;7.05,3.36,;8.3,2.45,;8.46,3.98,;6.12,1.26,;3.54,-1.95,;2.21,-1.18,)| | ||
| Structure | 
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