| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase 13 |
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| Ligand | BDBM649075 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HSD17b13 NAD(P)H-Glo Biochemical Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Hudson, AR; Govek, SP; Nagasawa, JY; Botrous, I; Smith, ND; Fasanya, KL HSD17B13 INHIBITORS AND USES THEREOF US Patent US20240034736 Publication Date 2/1/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase 13 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase 13 |
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| Synonyms: | 17-beta-HSD 13 | Hepatic retinol/retinal dehydrogenase | Short chain dehydrogenase/reductase family 16C member 3 | Short-chain dehydrogenase/reductase 9 |
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| Type: | Protein |
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| Mol. Mass.: | 33667.14 |
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| Organism: | Human |
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| Description: | Q7Z5P4 |
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| Residue: | 300 |
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| Sequence: | MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ
SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN
AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP
YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD
EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
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| BDBM649075 |
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| n/a |
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| Name | BDBM649075 |
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| Synonyms: | 2,6-Difluoro-3-(3-methyl-5-(methyl(tetrahydro- 2H-pyran-4-yl)amino)-1H-pyrazolo[4,3- d]pyrimidin-1-yl)-5-(trifluoromethyl)phenol | US20240034736, Compound 19.78 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18F5N5O2 |
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| Mol. Mass. | 443.3705 |
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| SMILES | CN(C1CCOCC1)c1ncc2n(nc(C)c2n1)-c1cc(c(F)c(O)c1F)C(F)(F)F |
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| Structure | 
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