| Reaction Details |
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 | Report a problem with these data |
| Target | enzyme inhibitor1 15-pgdh |
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| Ligand | BDBM650868 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Assay (1 nM) |
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| IC50 | 0.440±n/a nM |
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| Citation |  Markowitz, S; Antczak, M; Ready, J; Zhang, Y COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY US Patent US20240043440 Publication Date 2/8/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| enzyme inhibitor1 15-pgdh |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM650868 |
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| n/a |
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| Name | BDBM650868 |
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| Synonyms: | US20240043440, Example 61A |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20FN5OS2 |
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| Mol. Mass. | 441.545 |
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| SMILES | CCCC[S@@](=O)c1sc2nc(cc(-c3ccc(F)cc3)c2c1N)-c1cnc(N)nc1 |r| |
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| Structure | 
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