| Reaction Details |
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 | Report a problem with these data |
| Target | Dimer of Gag-Pol polyprotein [501-599] |
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| Ligand | BDBM9839 |
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| Substrate/Competitor | Fluorogenic Peptide Substrate |
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| Meas. Tech. | Protease Inhibition Assay |
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| Ki | 2.9±n/a nM |
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| Citation |  Stranix, BR; Sauve, G; Bouzide, A; Cote, A; Sevigny, G; Yelle, J; Perron, V Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-disubstituted ureas. Bioorg Med Chem Lett14:3971-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Dimer of Gag-Pol polyprotein [501-599] |
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| Name: | Dimer of Gag-Pol polyprotein [501-599] |
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| Synonyms: | HIV-1 Protease | HIV-1 Protease, recombinant, isolate HXB2 |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [501-599] |
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| Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10795.19 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03367[501-599] |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| Component 2 |
| Name: | Gag-Pol polyprotein [501-599] |
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| Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10795.19 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03367[501-599] |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| BDBM9839 |
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| Fluorogenic Peptide Substrate |
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| Name: | Fluorogenic Peptide Substrate |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 4156.59 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 39 |
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| Sequence: | DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS
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