Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM173376 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ca2+ flux Assay |
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Ki | 1.000±n/a nM |
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Citation | Alcazar Vaca, MJ; Andres Gil, JI; Letavic, MA; Rudolph, DA; Shireman, BT; Stenne, BM; Ziff, JM P2X7 modulators US Patent US9604982 Publication Date 3/28/2017 |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68403.50 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q64663 |
Residue: | 595 |
Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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BDBM173376 |
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n/a |
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Name | BDBM173376 |
Synonyms: | US10323032, Example 89 | US9096596, 89 | US9604982, Example 89 |
Type | Small organic molecule |
Emp. Form. | C19H17ClFN5O |
Mol. Mass. | 385.823 |
SMILES | C[C@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1F)nc(C)nc2-c1ccn[nH]1 |r| |
Structure |
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