| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-745,751-1210] |
|---|
| Ligand | BDBM313221 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | EGFR in vitro assay |
|---|
| Kd | 26.0±n/a nM |
|---|
| Citation |  Zhang, D Substituted pyrimidines useful as EGFR-T790M kinase inhibitors US Patent US10167264 Publication Date 1/1/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epidermal growth factor receptor [1-745,751-1210] |
|---|
| Name: | Epidermal growth factor receptor [1-745,751-1210] |
|---|
| Synonyms: | EGFR | EGFR (E746-A750del) | EGFR (del 746-750) | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(d746-750) | HER1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 133681.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00533[1-745,751-1210] |
|---|
| Residue: | 1205 |
|---|
| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTST
VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV
KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVW
ELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFS
SPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDT
FLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPT
CVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSS
EFIGA
|
|
|
|---|
| BDBM313221 |
|---|
| n/a |
|---|
| Name | BDBM313221 |
|---|
| Synonyms: | N-[3-[[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl] prop-2-enamide | US10167264, Compound 8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H26F3N7O2 |
|---|
| Mol. Mass. | 525.5255 |
|---|
| SMILES | CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
