| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-5 |
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| Ligand | BDBM160816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibitory Activity of Caspase |
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| IC50 | >3330±n/a nM |
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| Citation |  Ahlfors, J; Mekouar, K Selective caspase inhibitors and uses thereof US Patent US10167313 Publication Date 1/1/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Caspase-5 |
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| Name: | Caspase-5 |
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| Synonyms: | CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease |
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| Type: | Enzyme |
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| Mol. Mass.: | 49760.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51878 |
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| Residue: | 434 |
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| Sequence: | MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
RATLTRDFYLFPGN
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|
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| BDBM160816 |
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| n/a |
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| Name | BDBM160816 |
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| Synonyms: | US10167313, Compound 85 | US9045524, 85 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H41N5O11S |
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| Mol. Mass. | 751.803 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccccn1)NC(=O)[C@H](CC(O)=O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)\C=C\S(=O)(=O)c1ccccc1 |r| |
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| Structure | 
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