| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Ligand | BDBM173096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDE10A Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 7.60±n/a nM |
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| Comments | extracted |
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| Citation |  Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent US9669029 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Synonyms: | PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A) |
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| Type: | n/a |
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| Mol. Mass.: | 39060.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y233[440-779] |
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| Residue: | 340 |
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| Sequence: | ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLC
RFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRG
FSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKA
IIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTA
NDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTE
PLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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| BDBM173096 |
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| n/a |
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| Name | BDBM173096 |
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| Synonyms: | US9096589, 5,7-Dimethyl-2-[2-(4-thiophen-2-yl-1H-imidazol-2-yl)-ethyl]-imidazo[1,2-a]pyrimidine | US9669029, 17 5,7-Dimethyl-2-[2-(4-thiophen-2-yl-1H-imidazol-2-yl)-ethyl]-imidazo[1,2-a]pyrimidine |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N5S |
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| Mol. Mass. | 323.415 |
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| SMILES | Cc1cc(C)n2cc(CCc3nc(c[nH]3)-c3cccs3)nc2n1 |
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| Structure | 
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