Ki Summary

Reaction Details

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Target

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Ligand

BDBM50444038

Substrate/Competitor

n/a

Meas. Tech.

In Vitro Assay PDE10A

7.8±n/a

Temperature

298.15±n/a K

IC50

14±n/a nM

Comments

extracted

Citation

Megens, AA; Langlois, XJ; Andrés-Gil, JI Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders US Patent US9669035 Publication Date 6/6/2017

More Info.:

Get all data from this article, Assay Method

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Name:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Synonyms:

Type:

Enzyme

Mol. Mass.:

90160.88

Organism:

Rattus norvegicus (rat)

Description:

PDE10A was generated from the full-length recombinant rat clone transfected into Sf9 cells.

Residue:

794

Sequence:

MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKAD
GFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIG
PFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPAT
SKSTSEKPTRKVDD

BDBM50444038

n/a

Name

BDBM50444038

Synonyms:

CHEMBL3092563 | US9669035, B-5

Type

Small organic molecule

Emp. Form.

C21H19ClFN5O

Mol. Mass.

411.86

SMILES

Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1c(F)cccc1Cl |(32.38,-11.31,;31.04,-12.08,;29.71,-11.31,;28.38,-12.08,;27.05,-11.3,;25.72,-12.08,;25.72,-13.62,;24.39,-14.39,;23.06,-13.63,;23.06,-12.09,;21.73,-11.32,;20.39,-12.09,;20.39,-13.63,;21.73,-14.4,;27.05,-14.38,;28.38,-13.62,;29.71,-14.39,;30.03,-15.9,;31.56,-16.06,;32.19,-14.65,;31.04,-13.62,;28.92,-16.96,;27.44,-16.51,;27.08,-15.02,;26.32,-17.57,;26.68,-19.07,;28.16,-19.51,;29.28,-18.45,;30.75,-18.88,)|

Structure