Reaction Details |
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Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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Ligand | BDBM50026825 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Assay PDE2A |
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pH | 7.8±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 12±n/a nM |
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Comments | extracted |
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Citation | Megens, AA; Langlois, XJ; Andrés-Gil, JI Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders US Patent US9669035 Publication Date 6/6/2017 |
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More Info.: | Get all data from this article, Assay Method |
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cGMP-dependent 3',5'-cyclic phosphodiesterase |
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Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 105691.58 |
Organism: | Homo sapiens (Human) |
Description: | O00408 |
Residue: | 941 |
Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
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BDBM50026825 |
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n/a |
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Name | BDBM50026825 |
Synonyms: | CHEMBL3331518 | US9669035, B-12 |
Type | Small organic molecule |
Emp. Form. | C21H22N6O2 |
Mol. Mass. | 390.4384 |
SMILES | COc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12 |
Structure |
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