Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM315702 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kv11.1 (hERG) ION CHANNEL ACTIVITY (Patch Clamp Assay) | ||
Ki | 12500±n/a nM | ||
Citation | Fuchss, T; Emde, U; Buchstaller, H; Mederski, W Arylquinazolines US Patent US10172859 Publication Date 1/8/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM315702 | |||
n/a | |||
Name | BDBM315702 | ||
Synonyms: | US10172859, Example 126 | US10172859, Example 127 | US10172859, Example 128 | US11065253, Example 128 | US9732094, Example 128 | [2-Chloro-4-fluoro- 5-(6-morpholin-4- ylthieno[3,2-d}- pyrimidin-4-yl)- phenyl]-(6- methoxy- pyridazin-3-yl)- methanol (Ena 2)1H NMR (500 MHz, DMSO-d6) ppm = 8.90 (s,1H), 8.00 (d, J = 7.9, 1H), 7.69 (d, J = 9.2, 1H),7.66 (d, J = 10.0, 1H), 7.22 (d, J = 9.2, 1H), 6.62(d, J = 4.9, 1H), 6.54 (s, 1H), 6.22 (d, J = 4.9,1H), 3.99 (s, 3H), 3.77-3.72 (m, 4H), 3.45-3.39 (m, 4H) | ||
Type | Small organic molecule | ||
Emp. Form. | C22H19ClFN5O3S | ||
Mol. Mass. | 487.934 | ||
SMILES | COc1ccc(nn1)C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(sc12)N1CCOCC1 | ||
Structure |