| Reaction Details |
|---|
 | Report a problem with these data |
| Target | CARBONIC ANHYDRASE |
|---|
| Ligand | BDBM10869 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| Ki | 549±n/a nM |
|---|
| Citation |  Nishimori, I; Minakuchi, T; Morimoto, K; Sano, S; Onishi, S; Takeuchi, H; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. J Med Chem49:2117-26 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| CARBONIC ANHYDRASE |
|---|
| Name: | CARBONIC ANHYDRASE |
|---|
| Synonyms: | Carbonic Anhydrase (hpCA) | hpCA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28277.52 |
|---|
| Organism: | Helicobacter pylori J99 |
|---|
| Description: | Q9ZK30 |
|---|
| Residue: | 247 |
|---|
| Sequence: | MKKTFLIALALTASLIGAENTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNLKEVALDAFLPKS
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAETR
|
|
|
|---|
| BDBM10869 |
|---|
| BDBM10856 |
|---|
| Name | BDBM10869 |
|---|
| Synonyms: | 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide | CHEMBL6753 | aromatic/heteroaromatic sulfonamide 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C3H6N4O2S2 |
|---|
| Mol. Mass. | 194.235 |
|---|
| SMILES | Cn1nc(sc1=N)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
