| Reaction Details |
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 | Report a problem with these data |
| Target | CARBONIC ANHYDRASE |
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| Ligand | BDBM10881 |
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| Substrate/Competitor | BDBM10856 |
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| Meas. Tech. | CA Inhibition Assay |
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| Ki | 225±n/a nM |
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| Citation |  Nishimori, I; Minakuchi, T; Morimoto, K; Sano, S; Onishi, S; Takeuchi, H; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. J Med Chem49:2117-26 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| CARBONIC ANHYDRASE |
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| Name: | CARBONIC ANHYDRASE |
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| Synonyms: | Carbonic Anhydrase (hpCA) | hpCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28277.52 |
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| Organism: | Helicobacter pylori J99 |
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| Description: | Q9ZK30 |
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| Residue: | 247 |
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| Sequence: | MKKTFLIALALTASLIGAENTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNLKEVALDAFLPKS
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAETR
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| BDBM10881 |
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| BDBM10856 |
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| Name | BDBM10881 |
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| Synonyms: | CHEMBL288100 | MZA3 | Methazolamide | Methazolamide (MZA) | Methazolamide, MZA | N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide | Sulfonamide, 2 | cid_4100 | sulfonamide 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H8N4O3S2 |
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| Mol. Mass. | 236.272 |
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| SMILES | CC(=O)N=c1sc(nn1C)S(N)(=O)=O |w:3.2| |
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| Structure | 
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