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TargetCarbonic Anhydrase (hpCA)
LigandBDBM10902
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 12±n/a nM
Citation Nishimori IMinakuchi TMorimoto KSano SOnishi STakeuchi HVullo DScozzafava ASupuran CT Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. J Med Chem 49:2117-26 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic Anhydrase (hpCA)
Name:Carbonic Anhydrase (hpCA)
Synonyms:hpCA
Type:Enzyme
Mol. Mass.:28277.52
Organism:Helicobacter pylori J99
Description:Q9ZK30
Residue:247
Sequence:
MKKTFLIALALTASLIGAENTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNLKEVALDAFLPKS
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAETR
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  Blast E-value cutoff:
BDBM10902
BDBM10856
NameBDBM10902
Synonyms:2-N-(4-tert-butylbenzene)-1,3,4-thiadiazole-2,5-disulfonamide | 5-(4-tert-Butylphenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide | aromatic/heteroaromatic sulfonamide 36
TypeSmall organic molecule
Emp. Form.C12H16N4O4S3
Mol. Mass.376.475
SMILESCC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O
Structure
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