| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase |
|---|
| Ligand | BDBM11020 |
|---|
| Substrate/Competitor | BDBM11019 |
|---|
| Meas. Tech. | MAO Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | >1000000±n/a nM |
|---|
| Comments | no inhibition |
|---|
| Citation |  Hubalek, F; Binda, C; Khalil, A; Li, M; Mattevi, A; Castagnoli, N; Edmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem280:15761-6 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Amine oxidase |
|---|
| Name: | Amine oxidase |
|---|
| Synonyms: | Amine oxidase (flavin-containing) B | MAO-B | Monoamine Oxidase Type B (MAO-B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 50985.83 |
|---|
| Organism: | Ovis aries (sheep) |
|---|
| Description: | Mitochondrial preparation. |
|---|
| Residue: | 451 |
|---|
| Sequence: | RIHILTSDSGLQINQKNINSCISQGKSYPFRGSFPSVWNPIAYLDHNNLWRTMDDMGREI
PSDAPWKAPLAEQWDRMTMKELLDKICWTESSKQLAILFVNLCVSAEIHEVSALWFLWYV
KQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMELLGDRVKLERPVIHIDQTGENVLVET
LNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVYYKEPFWRNM
DYCGSMIIEGEEAPVAYTLDDTKPDGSYPAIIGFILAHKARKLARLTKEERLKKLCDLYA
KVLGSQEALHPVHYEEKNWCEEQYSAGCYTSYFPPGIMTQYGRVLRQPVGRIYFAGTETA
THWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTTFLQRHLPSV
PGLLKLIGLTTIISATALGYLAHKRGLLVRI
|
|
|
|---|
| BDBM11020 |
|---|
| BDBM11019 |
|---|
| Name | BDBM11020 |
|---|
| Synonyms: | 1,4-diphenyl-2-butene (DPB) | [(2E)-4-phenylbut-2-en-1-yl]benzene |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16 |
|---|
| Mol. Mass. | 208.2982 |
|---|
| SMILES | C(\C=C\Cc1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
