| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B [I199F] |
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| Ligand | BDBM11018 |
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| Substrate/Competitor | BDBM10999 |
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| Meas. Tech. | MAO Inhibition Assay |
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| Ki | >1000000±n/a nM |
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| Citation |  Hubalek, F; Binda, C; Khalil, A; Li, M; Mattevi, A; Castagnoli, N; Edmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem280:15761-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Amine oxidase [flavin-containing] B [I199F] |
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| Name: | Amine oxidase [flavin-containing] B [I199F] |
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| Synonyms: | AOFB_HUMAN | Amine oxidase (flavin-containing) B | MAOB | Monoamine Oxidase Type B (MAO-B) Mutant (I199F) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58802.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MAO B were expressed and purified from Pichia pastoris. |
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| Residue: | 520 |
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| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
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| BDBM11018 |
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| BDBM10999 |
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| Name | BDBM11018 |
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| Synonyms: | 2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine-4,6-dione | 8-(3-chlorostyryl)caffeine (CSC) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16ClN3O2 |
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| Mol. Mass. | 329.781 |
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| SMILES | CC1c2nc(\C=C\c3cccc(Cl)c3)n(C)c2C(=O)N(C)C1=O |
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| Structure | 
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