| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
|---|
| Ligand | BDBM318861 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In-Vitro Binding Assay |
|---|
| IC50 | <11.0±n/a nM |
|---|
| Citation |  Blank, J; Bold, G; Cotesta, S; Guagnano, V; Rueeger, H Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease US Patent US9624247 Publication Date 4/18/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 3 |
|---|
| Name: | Bromodomain-containing protein 3 |
|---|
| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 79571.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15059 |
|---|
| Residue: | 726 |
|---|
| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
|
|
|
|---|
| BDBM318861 |
|---|
| n/a |
|---|
| Name | BDBM318861 |
|---|
| Synonyms: | (R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(1H)-one | US9624247, Example 24 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20ClN7O |
|---|
| Mol. Mass. | 433.894 |
|---|
| SMILES | Cc1nnc2c(C)cc(nn12)N1[C@@H](c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
