Reaction Details |
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Target | Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
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Ligand | BDBM50329417 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay of Cdc7 Activity |
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IC50 | <100±n/a nM |
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Citation | Vanotti, E; Caldarelli, M; Cirla, A; Forte, B; Ermoli, A; Menichincheri, M; Pillan, A; Scolaro, A Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors US Patent US9670191 Publication Date 6/6/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
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Name: | Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
Synonyms: | Cdc7 Kinase | Cdc7/DBF4 |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cell division cycle 7-related protein kinase [58-574] |
Synonyms: | CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 57470.88 |
Organism: | Homo sapiens (Human) |
Description: | O00311[58-574] |
Residue: | 517 |
Sequence: | FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV
MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRD
VKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIP
LSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSS
ISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATD
KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA
SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS
DIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNE
VPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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Component 2 |
Name: | Protein DBF4 homolog A |
Synonyms: | ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1 |
Type: | Regulatory subunit |
Mol. Mass.: | 76869.65 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 674 |
Sequence: | MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
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BDBM50329417 |
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n/a |
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Name | BDBM50329417 |
Synonyms: | 5-(3-Fluoro-pyridin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide | CHEMBL1271441 | US9670191, E1 |
Type | Small organic molecule |
Emp. Form. | C16H12FN3O |
Mol. Mass. | 281.2844 |
SMILES | NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccncc1F |
Structure |
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