| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor XI |
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| Ligand | BDBM320262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibitory Effect of the Compounds of the Present Invention on the Enzymatic Activity of Blood-Coagulation Factor XIa |
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| Ki | 4.00±n/a nM |
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| Citation |  Wei, Y; Qiu, G; Zheng, S; Lei, B; Yu, Y; Chen, Y Pyridone or pyrimidone derivative, preparation method therefor and application thereof US Patent US10174020 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor XI |
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| Name: | Coagulation factor XI |
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| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
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| Type: | Enzyme |
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| Mol. Mass.: | 70130.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03951 |
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| Residue: | 625 |
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| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
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| BDBM320262 |
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| n/a |
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| Name | BDBM320262 |
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| Synonyms: | 5-[[2-[4-[5-chloro-2-(tetrazol-1-yl)phenyl]-2-oxo-1-pyridyl]-3-phenyl-propanoyl]amino]-1H-indole-2-carboxylic Acid | US10174020, Compound 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H22ClN7O4 |
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| Mol. Mass. | 579.993 |
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| SMILES | OC(=O)c1cc2cc(NC(=O)C(Cc3ccccc3)n3ccc(cc3=O)-c3cc(Cl)ccc3-n3cnnn3)ccc2[nH]1 |
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| Structure | 
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