| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM320770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Lab B PDE2 assay |
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| Ki | 0.058±n/a nM |
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| Citation |  Shen, D; Dwyer, MP; Sinz, CJ; Wang, D; Stachel, SJ; Paone, DV; Forster, A; Berger, R; Chen, Y; Qian, Y; Xu, S; Hu, C Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors US Patent US10174037 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | PDE2A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105104.20 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | n/a |
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| Residue: | 935 |
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| Sequence: | MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPPPPQPCADSLQDALLSLGSVIDISGLQRA
VKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSD
LPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLV
ALRRVQALQQRRPSEAPRAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQ
LKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSI
QLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVI
QHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSN
AEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPL
FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGI
SIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYT
PRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSH
FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVM
ERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEV
GYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRG
LPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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| BDBM320770 |
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| n/a |
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| Name | BDBM320770 |
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| Synonyms: | (R)- or (S)-6-(Dimethylamino)-3- (fluoromethyl)-1-(1-(4-isopropylphenyl)-2- methylpropyl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one | US10174037, Example 176 | US10174037, Example 177 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28FN5O |
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| Mol. Mass. | 385.4783 |
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| SMILES | CC(C)C(c1ccc(cc1)C(C)C)n1nc(CF)c2c1nc([nH]c2=O)N(C)C |
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| Structure | 
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