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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM323031
Substrate/Competitorn/a
Meas. Tech.FLAP Binding Assay (Test A)
IC50 8.60±n/a nM
Citation Broddefalk, JOEmtenäs, HFGranberg, KLLemurell, MAPettersen, DTPlowright, ATUlander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent US10183947 Publication Date 1/22/2019
More Info.:Get all data from this article,  Assay Method
 
Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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  Blast E-value cutoff:
BDBM323031
n/a
NameBDBM323031
Synonyms:(1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-[4-(5-methyl-1H-pyrazol- 3-yl)benzoyl]cyclohexanecarboxamide | US10183947, Example 15 | US10508119, Example 15 | US11001589, Example 15 | US11691978, Example 15
TypeSmall organic molecule
Emp. Form.C22H23F2N5O2
Mol. Mass.427.4471
SMILESCc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn[nH]c1C(F)F |r|
Structure
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